Cancer Research	Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention	Molecular Cancer Therapeutics
Molecular Cancer Research	Cell Growth & Differentiation

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Table 1 Catalytic efficiency (k_cat/K_m) of Pin1 and Pin1 mutants [M^-1s^-1]^a

Substrate Pin1 PPIase C113A R68L R69L R68,69L

Ac-AApSPR-pNA 3.1 x 10⁶ 1.6 x 10⁷ 1.1 x 10³ 1.4 x 10⁶ 3.9 x 10⁴ 7.0 x 10³

Ac-AASPR-pNA 2.9 x 10³ n.d. 0.9 x 10³ 2.7 x 10³ 2.9 x 10³ 2.5 x 10³

^{^a} The catalytic efficiency of the different proteins was calculated at a rate constant (k_obs.) of 0.012 s^-1 except for the mutant Pin1-C113A, with which the maximum rate constant (0.005 s^-1) was used for the calculations.

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